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Beyond chemotherapeutics: cisplatin as a temporary buckle to fabricate drug-loaded nanogels
Weiqi Zhang1, Zhe Zhang1, Ching-Hsuan Tung1
1Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, Cornell University, 413 East 69th Street, Box 290, New York, NY 10021, USA. cht2018@med.cornell.edu.
Chemical Communications (Cambridge, England)
|December 22, 2016
Abstract:
A cisplatin templated nanogel with targeting capability was synthesized, inspired by cisplatin as a chemotherapeutic drug. After crosslinking the natural polysaccharide hyaluronan, a ligand for CD44, cisplatin could be removed by simple dialysis in a salt solution while the withheld drug remains entrapped.
