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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Hedgehog Signaling Pathway02:33

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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Diversity in Cell Signaling Responses01:22

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The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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Overview of Cell Signaling01:23

Overview of Cell Signaling

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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Related Experiment Video

Updated: Mar 9, 2026

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions
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Control of signaling molecule range during developmental patterning.

Scott G Wilcockson1, Catherine Sutcliffe1, Hilary L Ashe2

  • 1Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK.

Cellular and Molecular Life Sciences : CMLS
|December 22, 2016
PubMed
Summary

Cells use diverse strategies to control signaling molecule range for precise embryonic development. These mechanisms ensure correct tissue patterning by regulating signal distribution and cellular communication.

Keywords:
BMPCytonemeDppEmbryoFGFHSPGHhNodal ECMSignalingTissue architectureWgWntstem cell

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Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
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Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
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Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Tissue Engineering

Background:

  • Embryonic development relies on intricate tissue patterning.
  • Signaling pathways regulate cell fate and tissue organization.
  • Signals can act over short or long distances within developing tissues.

Purpose of the Study:

  • To review strategies cells use to modulate signaling molecule range.
  • To explore mechanisms for restricting and extending signal range.
  • To understand how signaling range impacts tissue patterning.

Main Methods:

  • Review of existing literature on cell signaling and tissue patterning.
  • Analysis of mechanisms controlling signaling molecule diffusion and transport.
  • Examination of cellular structures involved in signal delivery and reception.

Main Results:

  • Cells employ mechanisms to restrict signaling molecule range, enabling precise control over adjacent cell fates.
  • Short-range signaling can generate concentration gradients crucial for developmental patterning.
  • Long-range signaling involves active transport via cellular structures like filopodia and exosomes.
  • Tissue architecture influences signaling molecule action and range.

Conclusions:

  • Modulating signaling molecule range is essential for accurate embryonic tissue patterning.
  • Diverse strategies, including active transport and architectural modulation, ensure correct signal distribution.
  • Understanding these mechanisms provides insights into developmental processes and potential therapeutic applications.