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Reduction of calprotectin and phosphate during testosterone therapy in aging men: a randomized controlled trial
L Pedersen1, L L Christensen2, S M Pedersen3
1Department of Clinical Chemistry, Holbæk Hospital, Smedelundsgade 60, 4300, Holbæk, Denmark. liseped@regionsjaelland.dk.
Objectives:
To investigate the effect of testosterone treatment on biomarkers calprotectin, fibroblast growth factor 23 (FGF23), soluble Klotho, phosphate, calcium, parathyroid hormone, creatinine and estimated glomerular filtration rate.
Design:
Randomized, double-blinded, placebo-controlled study.
Setting:
Odense Androgen Study-the effect of Testim and training in hypogonadal men.
Participants:
Men aged 60-78 years old with a low normal concentration of free of bioavailable testosterone <7.3 nmol/L and waist circumference >94 cm recruited from 2008 to 2009 (N = 48) by advertisement.
Intervention:
Participants were randomized to receive 5-10 g gel/50-100 mg testosterone (Testim®, Ipsen, France) or 5-10 g gel/placebo.
Results:
The plasma levels of calprotectin and phosphate were significantly reduced in the group receiving testosterone therapy (gel) compared to the placebo group (p < 0.05). Testosterone treatment did not have any significant effect on plasma levels of FGF23 or soluble Klotho. The reduction in phosphate levels was inversely associated with bioavailable testosterone.
Conclusion:
Compared to the placebo group, 6 months of testosterone therapy (gel) reduced calprotectin and phosphate levels suggesting decreased inflammation and decreased cardiovascular risk.
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