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Is still there a role for IL-2 for solid tumors other than melanoma or renal cancer?

Giandomenico Roviello1,2, Laura Zanotti2, Pierpaolo Correale3

  • 1Department of Molecular & Translational Medicine, University of Brescia, 25123 Brescia, Italy.

Immunotherapy
|December 22, 2016
PubMed
Abstract

Insights

Interleukin-2 (IL-2) combined with chemotherapy shows improved response rates in colorectal cancer patients. Further research is needed to explore IL-2

Area of Science:

  • Immunology
  • Oncology
  • Clinical Trials

Background:

  • Interleukin-2 (IL-2) is an immunomodulating cytokine used in cancer therapy.
  • Its efficacy in solid tumors beyond renal cancer and melanoma is not well-established.

Purpose of the Study:

  • To evaluate the effectiveness of IL-2 in treating solid tumors.
  • To determine the impact of IL-2 combined with chemotherapy on response rates.

Main Methods:

  • A meta-analysis of randomized controlled trials was conducted.
  • The primary outcome measure was the objective response rate.

Main Results:

  • The pooled risk ratio for objective response with IL-2 plus chemotherapy versus chemotherapy alone was 1.43 (95% CI: 1.12-1.81; p = 0.004).
  • This result favored the combination therapy, particularly in colorectal cancer.

Conclusions:

  • IL-2 in combination with chemotherapy demonstrates a significant benefit in objective response rates for colorectal cancer.
  • Further investigation of IL-2, alone or with chemotherapy, is warranted for colorectal cancer and other solid malignancies.
Keywords:
chemotherapyinterleukin-2solid tumor

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