[Subpopulations of peripheral blood T-lymphocytes in patients with chronic glomerulonephritis]

Patients with membranous proliferative glomerulonephritis in the presence of nephrotic syndrome of without it were investigated for subpopulation composition of T lymphocytes and their functional activity in pHA blast transformation test. Though no difference was revealed in E+- and Fc+-receptor occurrence, both spontaneous and PHA-induced malformation of autoreactive T cells were observed. The results justified the previous data on the deficiency in lymphopoiesis of undifferentiated cells with end deoxynucleotidyltransferase as a marker. In patients with nephrotic syndrome PHA-induced blast transformation test revealed a decrease in lymphocyte function.