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Updated: Mar 9, 2026
Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma
Published on: January 19, 2024
Glioblastoma in the elderly: treatment patterns and survival
Jean-Aine Pretanvil1, Isaac Q Salinas1, David E Piccioni1
1Department of Neurosciences, UCSD Moores Cancer Center, University of California San Diego, 3855 Health Science Drive, La Jolla, CA 92093-0819, USA.
Aim:
The optimal treatment for elderly glioblastoma patients is unclear. We conducted a retrospective review of the California Cancer Registry to examine treatment patterns and survival by age.
Methods:
We identified 2670 adult patients from the California Cancer Registry with glioblastoma. We compared the extent of resection, treatment type and modality.
Results:
Elderly patients had the greatest overall survival (OS) with combined surgery, radiation and chemotherapy. However, they were more likely to undergo biopsy and less likely to receive combined radiation and chemotherapy than patients <70.
Conclusion:
OS was maximized in elderly patients who were able to get some surgical resection and undergo combined radiation and chemotherapy. OS survival in some elderly patients may be improved by more extensive therapy.
