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Pre-eclampsia and risk of subsequent hypertension: in an American Indian population

Lyle G Best1, Laramie Lunday2, Elisha Webster2

  • 1a Turtle Mountain Community College , Natural Science Department , Belcourt , North Dakota , USA.

Hypertension in Pregnancy
|December 22, 2016
PubMed

Insights

History of pre-eclampsia (PE) significantly increases the risk of developing hypertension later in life. This risk is independent of other factors and can emerge within 8 years post-pregnancy.

Area of Science:

  • Obstetrics and Gynecology
  • Cardiovascular Disease Research
  • Public Health

Background:

  • Pre-eclampsia (PE) shares pathophysiologic links with cardiovascular disease (CVD), including endothelial dysfunction and inflammation.
  • PE is associated with increased long-term risks of hypertension, CVD, and mortality.

Purpose of the Study:

  • To investigate the long-term association between pre-eclampsia and subsequent hypertension.
  • To determine if the risk of hypertension post-PE is independent of other risk factors.

Main Methods:

  • Longitudinal study of 130 women with a history of PE and 289 controls.
  • Analysis of blood pressure, BMI, and medication use at a mean follow-up of 13.11 years.
  • Multivariate regression models adjusted for age, BMI, and early-pregnancy blood pressure.

Main Results:

  • A history of PE was independently associated with higher current systolic blood pressure (β = 4.47, p = 0.04).
  • Women with prior PE had a 3.43-fold increased odds of developing subsequent hypertension (95% CI 1.83-6.43, p = 0.001).
  • This association was evident within 7.19 years of follow-up and independent of other risk factors.

Conclusions:

  • Pre-eclampsia confers a significant, independent risk for developing hypertension in later life.
  • The risk of hypertension can manifest as early as 8 years post-PE.
  • Increased risk may be associated with more severe pre-eclampsia.
Abstract

Keywords:
Case–control studyhypertensionmultivariable analysispreeclampsia

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