The cancer cell adhesion resistome: mechanisms, targeting and translational approaches

Area of Science:

• Oncology
• Molecular Biology
• Cancer Research

Background:

• Cell adhesion to the extracellular matrix is a key factor in cancer therapy resistance.
• Two main paradigms, cell adhesion-mediated radioresistance (CAM-RR) and cell adhesion-mediated drug resistance (CAM-DR), have been identified.

Purpose of the Study:

• To review current knowledge on the cell adhesion resistome.
• To highlight strategies for targeting the cell adhesion resistome to overcome therapy resistance.

Main Methods:

• Review of preclinical and clinical studies on cell adhesion and cancer resistance.
• Analysis of molecular mechanisms underlying cell adhesion-mediated resistance.
• Identification of therapeutic targets within the cell adhesion resistome.

Main Results:

• The cell adhesion resistome plays a fundamental role in cancer cell adaptation and survival during therapy.
• Targeting integrins, adapter proteins, and kinases shows promise in sensitizing cancer cells to radiotherapy and chemotherapy.
• The cell adhesion resistome provides a basis for developing synthetic lethal targeted therapies.

Conclusions:

• Understanding the cell adhesion resistome is crucial for overcoming cancer therapy resistance.
• Targeting the cell adhesion resistome offers a promising strategy to enhance the efficacy of standard cancer treatments.
• Further research into synthetic lethal approaches targeting this pathway could revolutionize cancer therapy.