[Theoretical and practical aspects of the concept of traumatic disease]

The authors consider that the conception of "trauma disease" from the standpoint of practical medicine is of significance only for critical mainly associated injuries followed by acute alterations of vitally important functions. The basis of cause--effect relations forming the trauma disease as a nosological unit is the interrelationship of such pathogenetic factors as blood loss, respiratory and primary circulatory hypoxia, alteration of the central mechanisms of the regulation system, synchronous pathological impulsation from multiple foci of the injuries, hypodynamia and early endotoxicosis. The basis of treatment of the trauma disease is the early (within the first two days) elimination of these factors, performed by surgical measures and methods of pathogenetic intensive therapy.