Antiplatelet and Anticoagulation Therapy in Structural Heart Disease Interventions Beyond TAVI

Related Experiment Video

Updated: Mar 9, 2026

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
06:04

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation

Published on: August 8, 2025

673

Manolis Vavuranakis1, Konstantinos Dean Boudoulas2, Ourania Katsarou3

  • 113 Astypaleas, Anoixi, Attiki 14569, Greece.

Current Pharmaceutical Design
|December 23, 2016
PubMed

Insights

Transcatheter structural heart interventions require antiplatelet or anticoagulation therapy. This review summarizes current evidence for these treatments in procedures like left atrial appendage closure and atrial septal defect closure.

Area of Science:

  • Interventional Cardiology
  • Cardiovascular Medicine
  • Medical Device Technology

Background:

  • Transcatheter structural heart interventions are a rapidly advancing area in cardiology.
  • Antiplatelet and/or anticoagulation therapy is crucial before, during, and after these procedures.
  • Current treatment guidelines are primarily based on expert consensus.

Purpose of the Study:

  • To review and synthesize existing data on antiplatelet and anticoagulation strategies for specific transcatheter structural heart interventions.
  • To provide a comprehensive overview of current therapeutic recommendations.
  • To highlight areas for future research in anticoagulant and antiplatelet therapy.

Main Methods:

  • Literature review of studies on antiplatelet and anticoagulation treatments.
  • Focus on interventions including left atrial appendage closure, atrial septal defect closure, patent foramen oval closure, and paravalvular leak closure.
  • Synthesis of data based on published evidence and expert opinion.

Main Results:

  • Evidence for specific antiplatelet and anticoagulation regimens varies across different structural heart interventions.
  • Expert consensus plays a significant role in guiding current practices.
  • Optimal therapeutic strategies are still evolving for many procedures.

Conclusions:

  • Standardized evidence-based guidelines for antiplatelet and anticoagulation therapy in transcatheter structural heart interventions are needed.
  • Further research is essential to optimize patient outcomes and minimize bleeding risks.
  • Tailoring therapy based on individual patient risk factors and procedural type is crucial.

Keywords:
ASDLAANOACPFOantiplateletcoumadintranscatheterwarfarin

More Related Videos

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

6.1K
Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement08:50

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement

Published on: March 26, 2018

12.4K

Related Concept Videos

Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
357
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
472
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
541
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
1.4K
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
433
Angina IV: Management01:26

Angina IV: Management

IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
372