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A circuit for saccadic suppression in the primate brain.

Rebecca A Berman1, James Cavanaugh2, Kerry McAlonan2

  • 1Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland bermanr@mail.nih.gov.

Journal of Neurophysiology
|December 23, 2016
PubMed
Summary

The brain suppresses visual blur during rapid eye movements (saccades) using a circuit from the superior colliculus (SC) to the middle temporal area (MT). This saccadic suppression is driven by corollary discharge signals, preventing visual disruption.

Keywords:
corollary dischargemacaquesuppression

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Area of Science:

  • Neuroscience
  • Visual processing
  • Oculomotor control

Background:

  • Rapid eye movements, known as saccades, can cause visual blur.
  • Brain mechanisms, including saccadic suppression, prevent perception of this blur.
  • Neuronal correlates of saccadic suppression have been identified in the superior colliculus (SC) and middle temporal visual area (MT).

Purpose of the Study:

  • Investigate saccadic suppression in the circuit linking visual SC (SCs) to MT via the inferior pulvinar (PI).
  • Identify the neuronal basis of suppression driven by corollary discharge signals.
  • Determine the role of SC input in MT suppression.

Main Methods:

  • Recorded neuronal responses to visual stimuli before saccades in SCs, PI, and MT.
  • Examined suppression during saccades into both visual hemifields.
  • Inactivated SC neurons to test their influence on MT suppression.

Main Results:

  • Visual responses were suppressed in SCs, PI, and MT.
  • Suppression occurred for saccades into both hemifields, but consistently began pre-saccade (~100 ms) only in the contralateral hemifield.
  • Inactivation of SC neurons provided evidence that MT suppression depends on corollary discharge from motor SC (SCi).

Conclusions:

  • A circuit originating from SCi corollary discharge signals produces suppression in SCs, PI, and MT.
  • This circuit contributes to the neuronal suppression of visual signals during eye movements.
  • The findings elucidate a fundamental mechanism preventing visual disruption during saccades.