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Multicenter Study of the Clinical Presentation of Staphylococcus lugdunensis Bacteremia in Japan

Yusuke Ainoda1,2,3, Nozomi Takeshita1, Ryota Hase4,5

  • 1Disease Control and Prevention Center, National Center for Global Health and Medicine.

Japanese Journal of Infectious Diseases
|December 23, 2016
PubMed

Insights

Staphylococcus lugdunensis (SL) bacteremia is rare but serious in Japan. This study found SL in 0.28% of bacteremia cases, highlighting the need for clinical awareness of this pathogen.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Staphylococcus lugdunensis (SL) is a coagulase-negative Staphylococcus species (CoNS) with notable pathogenicity.
  • Limited data exist on the prevalence and clinical significance of SL in Japan.
  • The current prevalence of SL bacteremia in Japan remains unknown.

Purpose of the Study:

  • To determine the prevalence of Staphylococcus lugdunensis bacteremia in Japan.
  • To assess the clinical characteristics and outcomes of SL bacteremia.

Main Methods:

  • A prospective, multicenter study was conducted across 5 healthcare facilities.
  • Blood culture specimens from 3,284 patients with positive cultures were analyzed.
  • Patients with bacteremia were identified, and the proportion of SL bacteremia was calculated.

Main Results:

  • Out of 2,478 patients with bacteremia, 7 (0.28%) had SL bacteremia.
  • SL accounted for 2.49% of all coagulase-negative Staphylococcus spp. (CoNS) bacteremia cases (281 total).
  • One patient (14.3%) developed infective endocarditis, and another (14.3%) died within 30 days.

Conclusions:

  • Staphylococcus lugdunensis can cause bacteremia in Japanese patients.
  • Clinicians should be aware of SL's prevalence and potential complications, including infective endocarditis and mortality.
  • Further surveillance and research are warranted to understand SL epidemiology in Japan.
Keywords:
JapanStaphylococcus lugdunensisincidence

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