Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

9.9K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
9.9K
Cytoskeletal Linker Proteins - Plakins01:09

Cytoskeletal Linker Proteins - Plakins

3.0K
Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human Fecal Microbiota Transplantation Reduces the Susceptibility to Dextran Sulfate Sodium-Induced Germ-Free Mouse Colitis.

Frontiers in immunology·2022
Same author

Correlation between the regulation of intestinal bacteriophages by green tea polyphenols and the flora diversity in SPF mice.

Food & function·2022
Same author

Oral Administration of Bacterial <i>β</i> Cell Expansion Factor A (BefA) Alleviates Diabetes in Mice with Type 1 and Type 2 Diabetes.

Oxidative medicine and cellular longevity·2022
Same author

Neonatal Adverse Events' Trigger Tool Setup With Random Forest.

Journal of patient safety·2022
Same author

Diffusion MRI super-resolution reconstruction via sub-pixel convolution generative adversarial network.

Magnetic resonance imaging·2022
Same author

A Combined-Radiomics Approach of CT Images to Predict Response to Anti-PD-1 Immunotherapy in NSCLC: A Retrospective Multicenter Study.

Frontiers in oncology·2022

Related Experiment Video

Updated: Mar 9, 2026

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

2.0K

[Research progress of Krüppel-like factor 7].

Yue-Chan Chen1,2, Hong Wei1, Zhi-Wei Zhang3

  • 1Department of Basic Medicine, School of Medicine, Shihezi University, Shihezi 832000, China.

Sheng Li Xue Bao : [Acta Physiologica Sinica]
|December 23, 2016
PubMed
Summary

Krüppel-like factor 7 (KLF7) is a key transcription factor involved in various human health conditions, including obesity, diabetes, and cancer. Research highlights its roles in nervous system, adipose tissue, and cardiovascular disease regulation.

More Related Videos

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses
07:42

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses

Published on: July 13, 2016

73.7K
Identification of Functional Protein Regions Through Chimeric Protein Construction
11:39

Identification of Functional Protein Regions Through Chimeric Protein Construction

Published on: January 8, 2019

11.0K

Related Experiment Videos

Last Updated: Mar 9, 2026

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

2.0K
Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses
07:42

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses

Published on: July 13, 2016

73.7K
Identification of Functional Protein Regions Through Chimeric Protein Construction
11:39

Identification of Functional Protein Regions Through Chimeric Protein Construction

Published on: January 8, 2019

11.0K

Area of Science:

  • Genetics
  • Molecular Biology
  • Human Physiology

Background:

  • Krüppel-like factor 7 (KLF7), also known as ubiquitous Krüppel-like factor (UKLF), is widely expressed in adult human tissues.
  • Genetic variations and methylation patterns of KLF7 are linked to significant health issues such as obesity, type 2 diabetes, and gastric cancer.
  • KLF7 is implicated in the regulatory networks of cardiovascular disease markers and plays a role in maintaining pluripotent cells.

Purpose of the Study:

  • To review the current research progress on Krüppel-like factor 7 (KLF7).
  • To summarize KLF7's genetic characteristics, protein structure, and gene functions.
  • To consolidate understanding of KLF7's multifaceted roles in human health and disease.

Main Methods:

  • Literature review of genetic, genomic, and functional studies.
  • Analysis of research on KLF7's association with various diseases.
  • Synthesis of findings related to KLF7's regulatory roles.

Main Results:

  • KLF7 genetic polymorphism is associated with obesity, type 2 diabetes, and mental development.
  • KLF7 methylation is linked to diffuse gastric cancer development.
  • KLF7 acts as a key transcription factor in cardiovascular disease marker regulation and influences nervous system, adipose tissue, and blood cell development.

Conclusions:

  • KLF7 is a crucial transcription factor with diverse roles in human physiology and disease pathogenesis.
  • Further research into KLF7's mechanisms can offer insights into treating metabolic, cardiovascular, and oncological diseases.
  • Understanding KLF7's genetic and functional aspects is vital for advancing personalized medicine approaches.