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Updated: Mar 9, 2026

Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus
Published on: March 28, 2025
Hints for control of infection in unique extrahepatic vertebral alveolar echinococcosis
Jean-François Faucher1, Cécile Descotes-Genon2, Bruno Hoen2
1Service des maladies infectieuses et Tropicales, Centre Hospitalier Universitaire, Besançon, 25030, Besançon cedex, France. jffaucher@free.fr.
Abstract:
The prognosis of vertebral alveolar echinococcosis (AE) is poor. We report on the unique outcome of a patient with preexisting liver cirrhosis, in whom a diagnosis of vertebral AE was established on vertebral histopathology (D4 corporectomy in 2010 for paraplegia). Therapeutic drug monitoring of albendazole (ABZ) showed that a low dosage was appropriate. The patient recovered and ABZ withdrawal was decided in 2014, with no relapse 18 months later. In this patient, infection was purely or mainly localized in the dorsal spine, and this may have been favored by liver cirrhosis. A longer follow-up is, however, needed to confirm cure.

