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Issues in contemporary and potential future molecular diagnostics for dengue.

Shamala Devi Sekaran1, Hui Jen Soe1

  • 1a Department of Medical Microbiology, Faculty of Medicine , University of Malaya , Kuala Lumpur , Malaysia.

Expert Review of Molecular Diagnostics
|December 23, 2016
PubMed
Summary

Accurate dengue diagnosis is crucial for patient care and disease control. New molecular diagnostic tools, including biosensors and nanotechnology, are expected to improve rapid and sensitive detection of dengue virus.

Keywords:
DengueNAATsbiosensormicroarraymolecular diagnosis

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Area of Science:

  • Medical Entomology
  • Infectious Diseases
  • Molecular Diagnostics

Background:

  • Dengue is a widespread arbovirus infection affecting 2.5 billion people globally.
  • Under-reporting of dengue cases is common due to asymptomatic infections and non-specific symptoms, impacting surveillance.
  • Effective dengue diagnosis requires rapid, sensitive, specific, and inexpensive tools for clinical management and intervention development.

Purpose of the Study:

  • To review current dengue diagnostic tools, focusing on molecular methods.
  • To explore emerging molecular diagnostic technologies like biosensors and microarrays for dengue detection.

Main Methods:

  • Overview of nucleic acid amplification tests (NAATs) for dengue diagnosis.
  • Discussion of potential molecular diagnostic tools including biosensors and microarrays.

Main Results:

  • Nucleic acid amplification tests represent a key area in contemporary dengue molecular diagnostics.
  • Biosensors and microarray technologies show promise as future molecular diagnostic tools for dengue.

Conclusions:

  • Rapid and accurate dengue diagnosis is essential for effective clinical management and public health surveillance.
  • Future dengue diagnostics will likely incorporate advanced technologies like biosensors and nanotechnology.
  • Validation of new dengue diagnostic technologies is critical, addressing sensitivity, specificity, and cross-reactivity.