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Updated: Mar 9, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Non-Deprotonative Primary and Secondary Amination of (Hetero)Arylmetals
Zhe Zhou1, Zhiwei Ma1, Nicole Erin Behnke1
1Department of Chemistry, Rice University , BioScience Research Collaborative, 6500 Main Street, Rm 380, Houston, Texas 77030, United States.
Abstract:
Herein we disclose a novel method for the facile transfer of primary (-NH2) and secondary amino groups (-NHR) to heteroaryl- as well as arylcuprates at low temperature without the need for precious metal catalysts, ligands, excess reagents, protecting and/or directing groups. This one-pot transformation allows unprecedented functional group tolerance and it is well-suited for the amination of electron-rich, electron-deficient as well as structurally complex (hetero)arylmetals. In some of the cases, only catalytic amounts of a copper(I) salt is required.
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