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Related Concept Videos

Design Example: Managing Concrete Workability01:14

Design Example: Managing Concrete Workability

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This example deals with managing the workability of concrete for a raft foundation project under hot weather conditions. Workability is crucial for ensuring the concrete is easy to place, compact, and finish. In this scenario, a slump test — a common method to measure the workability of fresh concrete — initially indicated low workability. This was attributed to the rapid water loss from the concrete mix, exacerbated by the high temperatures causing the course aggregates to heat up.
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Design Consideration01:22

Design Consideration

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Designing a structure involves a series of considerations, primarily the material's ultimate strength, calculated through tests that measure changes under increased force until the material reaches its breaking point or limit. The ultimate load, where the material breaks, is divided by its original cross-sectional area, resulting in the ultimate normal stress or strength. The ultimate shearing stress is another significant factor taken into account.
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Design Example: Sustainability in Concrete Building01:26

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As the construction industry moves towards more eco-friendly practices, concrete's adaptability and its ability to incorporate sustainable features make it a key material in the drive towards greener building solutions.
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Design Example: Designing Water Slide01:18

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When designing a water slide, controlling the speed of water flow is crucial for rider safety while maintaining an exciting experience. As water flows down the slide, gravity causes it to accelerate, with its speed at the bottom depending on the height from which it starts. The higher the slide, the more potential energy the water has at the top, which is converted into kinetic energy as it descends, increasing its speed.
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Optimization Problems01:26

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Optimization problems often involve identifying maximum or minimum values under specific constraints. A well-known example is determining the longest horizontal pipe that can be moved around a right-angled corner, where a 3-meter-wide hallway meets a 2-meter-wide hallway. This scenario, common in architectural design and industrial transport, can be understood conceptually through geometric and trigonometric reasoning.To visualize the problem, consider the pipe as a straight line that touches...
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The design of prismatic beams, structural elements with a uniform cross-section, focuses on ensuring safety and structural integrity under load. The design process begins by determining the allowable stress, either from material properties tables, or by dividing the material's ultimate strength by a safety factor. This safety factor is essential for accommodating uncertainties, and varies depending on the material—timber, steel, or concrete—with each having unique strength and...
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Design and Optimization Strategies of a High-Performance Vented Box
14:23

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Streamlining the Design-to-Build Transition with Build-Optimization Software Tools.

Ernst Oberortner1, Jan-Fang Cheng1, Nathan J Hillson1,2

  • 1DOE Joint Genome Institute , 2800 Mitchell Drive, Walnut Creek, California 94598, United States.

ACS Synthetic Biology
|December 23, 2016
PubMed
Summary
This summary is machine-generated.

This study introduces BOOST, a software tool that optimizes synthetic biology DNA construct design for manufacturability. BOOST reduces DNA synthesis costs and timelines by ensuring sequences meet manufacturing constraints.

Keywords:
DNA synthesisbioCAD/CAMdesign−build−testsynthetic biology

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Area of Science:

  • Synthetic biology
  • DNA synthesis
  • Bioengineering

Background:

  • Scaling synthetic biology requires efficient design, build, and test workflows.
  • Current biological computer-aided design and manufacture (bioCAD/CAM) tools do not account for DNA synthesis limitations.
  • Sequence redesign due to synthesis constraints increases costs and delays manufacturing.

Purpose of the Study:

  • To develop a software tool that streamlines the transition from DNA construct design to manufacturing.
  • To integrate knowledge of DNA synthesis success factors into the design process.
  • To reduce costs and timelines associated with DNA synthesis in synthetic biology.

Main Methods:

  • Development of a suite of build-optimization software tools (BOOST).
  • Incorporation of DNA synthesis success determinants into the design process.
  • Creation of a web application and APIs for BOOST.

Main Results:

  • BOOST outputs ready-to-build DNA sequences, minimizing redesign.
  • The software effectively reduces DNA synthesis costs.
  • Timelines for DNA manufacturing are significantly shortened.

Conclusions:

  • BOOST enhances the efficiency of synthetic biology engineering workflows.
  • The tool preempts redesign by generating manufacturable sequences.
  • BOOST facilitates the scaling of synthetic biology applications.