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Stimuli-Responsive Self-Assembled DNA Nanomaterials for Biomedical Applications
Ziwen Dai1,2, Hoi Man Leung1, Pik Kwan Lo1,2
1Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.
Small (Weinheim an Der Bergstrasse, Germany)
|December 23, 2016
Summary
Stimuli-responsive DNA nanostructures offer versatile platforms for advanced nano-biotechnology. This review details their design, response mechanisms, and applications in biosensing, drug delivery, and bio-computing.
Area of Science:
- Biotechnology and Nanomaterials Science
Background:
- Stimuli-responsive DNA-based materials are a key class of functional nanomaterials.
- Self-assembled DNA nanostructures are increasingly utilized for nano-biotechnological applications.
Purpose of the Study:
- To review recent advancements in stimuli-responsive systems based on self-assembled DNA nanostructures.
- To classify these systems and present examples based on design, working principles, and response mechanisms.
Main Methods:
- Classification of stimuli-responsive DNA nanostructures.
- Presentation of representative examples detailing design and working principles.
- Analysis of response mechanisms to various stimuli (pH, ions, molecules, enzymes, heat, light).
Main Results:
- Demonstrated advantages of stimuli-responsive DNA nanomaterials in various biomedical applications.
- Successful in vitro studies highlighting potential in biosensing, drug delivery, therapy, diagnostics, and bio-computing.
- Identification of challenges and future development directions.
Conclusions:
- Stimuli-responsive DNA nanostructures are highly promising for diverse nano-biotechnological applications.
- Further research is needed to overcome current challenges and fully realize their potential in biomedical fields.
