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Related Experiment Video

Updated: Mar 9, 2026

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment

Published on: June 28, 2018

Exposure Memory and Lung Regeneration.

Young-Mi Go¹, Dean P Jones¹

¹Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Clinical Biomarkers Laboratory, Emory University, Atlanta, Georgia.

Annals of the American Thoracic Society

|December 23, 2016

Summary

This summary is machine-generated.

Environmental exposures create memory that impacts lung regeneration. Understanding this exposure memory is crucial for developing effective lung regeneration therapies and transitioning them into clinical practice.

Keywords:

aging environmental exposure occupational exposure oxidative stress redox code

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Area of Science:

Pulmonary Medicine
Regenerative Medicine
Redox Biology

Background:

Acute and chronic lung diseases necessitate improved regeneration therapies.
Genetically encoded exposure memory systems influence phenotypic adaptation throughout life.
The role of exposure memory in lung regeneration remains largely unexplored.

Purpose of the Study:

To provide a framework using redox biology and medicine to understand exposure memory in lung regeneration.
To delineate spatiotemporal responses influenced by prior and ongoing environmental exposures.
To highlight the need for research into lifelong exposure impacts on lung biology.

Main Methods:

Overview of advances in redox biology and medicine.
Discussion of new imaging and omics methods for precise biological definition.
Framework for understanding cumulative changes from environmental exposures.

Main Results:

Exposure memory systems can direct phenotypic adaptation and responses in the lung.
New technologies allow detailed characterization of lung biochemistry, structure, and cell populations.
Prior and ongoing exposures cumulatively alter lung biology.

Conclusions:

Effective lung regeneration may require conditioning to reverse detrimental exposure memory.
Systematic knowledge of lifelong exposure impacts is needed.
Transitioning lung regeneration from theoretical to practical medicine requires this knowledge.