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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
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The impact of blood pressure variability on coronary plaque vulnerability in stable angina: an analysis using optical

Rie Aoyama1, Hitoshi Takano, Keishi Suzuki

  • 1Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan.

Coronary Artery Disease
|December 23, 2016
PubMed

Insights

Blood pressure variability (BPV) correlates with coronary plaque volume but not vulnerability. BPV may be a therapeutic target for coronary atherosclerosis, alongside traditional risk factors.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Hypertension Research

Background:

  • Visit-to-visit blood pressure variability (BPV) is a known cardiovascular risk factor.
  • The specific impact of BPV on coronary plaque vulnerability is not well understood.
  • This study investigates the link between BPV and coronary plaque characteristics.

Purpose of the Study:

  • To examine the relationship between blood pressure variability and coronary plaque vulnerability.
  • To assess if BPV influences lipid core size and fibrous cap thickness.

Main Methods:

  • Retrospective analysis of 36 patients with hypertension and stable angina undergoing percutaneous coronary intervention.
  • Frequency-domain optical coherence tomography (FD-OCT) used to measure lipid core size and fibrous cap thickness.
  • Intraindividual visit-to-visit BPV quantified using systolic blood pressure (SBP) standard deviation (SD) and coefficient of variation (CV).

Main Results:

  • SBP-SD and SBP-CV showed a positive correlation with lipid arc size.
  • Average SBP also correlated positively with lipid arc.
  • No significant correlation was found between fibrous cap thickness and BPV measures.

Conclusions:

  • Blood pressure variability is associated with increased coronary plaque volume (lipid arc).
  • BPV does not appear to be directly related to coronary plaque vulnerability (fibrous cap thickness).
  • BPV represents a potential therapeutic target for managing coronary atherosclerosis.
Abstract

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