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Low-Molecular-Weight Heparin for the Prevention of Placenta-mediated Pregnancy Complications

Bassam Haddad1, Edouard Lecarpentier, Cyril Touboul

  • 1*Department of Obstetrics, Gynecology, and Reproductive Medicine, University Paris Est Créteil, CRC Centre Hospitalier Intercommunal de Créteil, Créteil, France †Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division, McGovern Medical School at UT Health, Houston, Texas.

Clinical Obstetrics and Gynecology
|December 23, 2016
PubMed

During the past decade, prophylactic doses of low-molecular-weight heparin (LMWH) have been suggested to decrease the risk of placental-mediated complications. Herein, we review the prospective randomized trials that addressed the usefulness of LMWH in preventing placental-mediated complications in high-risk women. Inclusion criteria and results of these trials are heterogeneous. Unlike older trials (3 of 4 are single center), recent trials (all are multicenter) do not show beneficial effect of LMWH. There is certainly a need of complementary research before stating on the usefulness of LMWH in the prevention of placenta-mediated pregnancy complications in women at high risk.

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