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Updated: Mar 9, 2026
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
High glomerular filtration rate is associated with arterial stiffness in Chinese population
1aState Key Laboratory of Medical Genomics, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems BiomedicinebShanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Insights
High glomerular filtration rate (GFR), known as renal hyperfiltration (RHF), is linked to increased arterial stiffness in Chinese adults. This finding suggests RHF may serve as an early indicator for detecting arterial stiffness.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Public Health
Background:
- Decreased glomerular filtration rate (GFR) is a known risk factor for arterial stiffness.
- The association between high GFR and arterial stiffness or cardiovascular disease remains unclear.
Purpose of the Study:
- To investigate the relationship between high estimated GFR (eGFR) and arterial stiffness in a Chinese adult population.
- To determine if renal hyperfiltration (RHF) is associated with arterial stiffness.
Main Methods:
- Cross-sectional study of 9136 Chinese adults without chronic kidney disease.
- Arterial stiffness assessed by brachial-ankle pulse wave velocity (baPWV) and pulse pressure (PP).
- Participants categorized into quartiles of age-specific eGFR, with the highest quartile defined as RHF; logistic regression and propensity score matching used for analysis.
Main Results:
- Renal hyperfiltration (RHF) showed a significant association with increased risk of elevated baPWV (adjusted OR 1.17; 95% CI 1.03-1.30) and elevated PP (adjusted OR 1.28; 95% CI 1.13-1.46).
- These associations remained significant after adjusting for covariates and were confirmed by propensity score matching.
- Age-adjusted models also indicated a higher risk of elevated PP with RHF (P=0.005).
Conclusions:
- Renal hyperfiltration (RHF) is significantly associated with elevated brachial-ankle pulse wave velocity (baPWV) and pulse pressure (PP).
- These findings suggest that RHF may serve as an early indicator for the detection of arterial stiffness.
- Further research is warranted to explore the clinical implications of RHF in cardiovascular health.
Objectives:
Decreased glomerular filtration rate (GFR) has been suspected as a risk factor for arterial stiffness. Whether high GFR is the risk factor of arterial stiffness and cardiovascular disease remains uncertain. We aim to evaluate the association between high estimated GFR (eGFR) and arterial stiffness in Chinese adults.
Methods:
We performed a cross-sectional study involving 9136 Chinese adults without chronic kidney disease. Arterial stiffness was measured by brachial-ankle pulse wave velocity (baPWV) and pulse pressure (PP). We divided participants into four groups according to age-specific quartiles of eGFR. Renal hyperfiltration (RHF) was defined with the highest age-specific quartile of eGFR. The odds ratios (ORs) of elevated baPWV and PP were estimated using multivariate logistic regression models and were further tested using propensity score matching analysis between participants with or without RHF.
Results:
RHF was associated with 11 and 32% higher risk of elevated baPWV and PP in age-adjusted models, P = 0.35 and 0.005, respectively. After adjusting for covariates, RHF was significantly associated with 23 and 39% increased risk of elevated baPWV and PP, P = 0.01 and 0.001, respectively. These associations were further confirmed in propensity score matching analysis. The adjusted ORs (95% confidence interval) were 1.17 (1.03-1.30) for elevated baPWV and 1.28 (1.13-1.46) for elevated PP, P = 0.02 and P value less than 0.001, respectively.
Conclusion:
RHF was associated with elevated baPWV and PP, suggesting that RHF might be an early indicator for the detection of arterial stiffness.
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