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A Protocol for Decellularizing Mouse Cochleae for Inner Ear Tissue Engineering

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Bone Marrow Stem Cells and Ear Framework Reconstruction.

Hamid Karimi¹, Seyed-Abolhassan Emami, Mohammad-Kazem Olad-Gubad

¹*Department of Plastic and Reconstructive Surgery, Faculty of Medicine†Department of Plastic and Reconstructive Surgery, Hazrat Fatemeh Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

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|December 23, 2016

Summary

This summary is machine-generated.

Human mesenchymal stem cells successfully maintained the size, shape, and flexibility of ear cartilage grafts. This innovative technique shows promise for reconstructing total ear defects in plastic surgery.

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Area of Science:

Regenerative Medicine
Biomaterials Science
Plastic and Reconstructive Surgery

Background:

Reconstructing total human ear loss or congenital ear defects presents significant challenges in plastic surgery.
Current methods often struggle to achieve natural form and function.

Purpose of the Study:

To investigate the 3D reconstruction of human ear structures using cadaveric ear cartilages.
To evaluate the efficacy of seeding these cartilages with human mesenchymal stem cells.

Main Methods:

Cadaveric ear cartilages with perichondrium were used, divided into two groups: cartilage alone (Group A) and cartilage seeded with human mesenchymal stem cells (Group B).
Group B samples were implanted in athymic rats for 12 weeks.
Evaluated parameters included size, weight, shape, flexibility, and chondrocyte viability.

Main Results:

Group A showed significant reductions in size and weight, with diminished shape and flexibility.
Microscopic examination of Group A revealed very few viable chondrocytes.
Group B samples maintained size, weight, shape, and flexibility, with abundant viable chondrocytes observed.

Conclusions:

Seeding cadaveric ear cartilage with human mesenchymal stem cells significantly preserves structural integrity and cell viability.
This approach offers a viable method for the reconstruction of complete ear defects in humans.