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Prediction of Coronary Artery Disease Extent and Severity Using Pulse Wave Velocity

Joseph Chiha1, Paul Mitchell2, Bamini Gopinath2

  • 1Centre for Heart Research, Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia.

Plos One
|December 23, 2016
PubMed

Insights

Pulse-wave velocity (PWV) measures aortic stiffness and predicts cardiovascular events. This study found PWV correlates with coronary artery disease (CAD) extent in men but not obstructive CAD severity in either gender.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Physiology
  • Diagnostic Imaging

Background:

  • Pulse-wave velocity (PWV) is a validated marker of aortic stiffness and an independent predictor of cardiovascular events and mortality.
  • Limited research exists on the association between PWV and the severity or extent of coronary artery disease (CAD).

Purpose of the Study:

  • To investigate the utility of PWV in predicting the burden of CAD in both men and women.
  • To evaluate the relationship between PWV, coronary scores (Extent, Gensini, vessel), and traditional cardiovascular risk factors.

Main Methods:

  • PWV was measured in 344 patients undergoing invasive coronary angiography for suspected CAD.
  • Pearson correlations and multivariate analyses were employed to assess relationships between coronary scores, PWV, and risk factors.
  • Patient cohort included 266 men and 78 women.

Main Results:

  • Women exhibited significantly lower Extent and Gensini scores compared to men.
  • PWV was similar between genders and correlated with the Extent score (r=0.21, p=0.0001), but not Gensini or vessel scores.
  • PWV showed a significant association with Extent score in men (B=2.25, p=0.004) but not in women (B=1.50, p=0.09).

Conclusions:

  • PWV correlates with the extent of CAD, particularly in men, but not with the severity of obstructive CAD in either gender.
  • PWV may serve as a useful, non-invasive indicator for the extent of coronary atherosclerosis, especially in male populations.
Abstract

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