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Updated: Mar 9, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
ent-Labdane Diterpenoids from Dodonaea viscosa
Wesley J Olivier1, Nathan L Kilah1, James Horne1
1School of Physical Sciences-Chemistry and ‡Central Science Laboratory, University of Tasmania , Hobart, Tasmania, Australia.
Abstract:
Seven new and two known ent-labdane diterpenoids have been isolated from a single plant specimen of Dodonaea viscosa ssp. spatulata, found in Tasmania, Australia. Prior to this study, only seven different labdane diterpenoids had been isolated from D. viscosa. The structures of the natural products were assigned via 1D and 2D NMR spectroscopy and other standard spectroscopic methods. The absolute configuration of three ent-labdane diterpenoids was determined by single-crystal X-ray crystallography of synthetic derivatives. Significantly, the results of this study suggest that the absolute configuration of some known labdane diterpenoids may have been misassigned.
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