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Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
Published on: January 21, 2020
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[Complex regional pain syndrome: A review].
Berenice Carolina Hernández-Porras1, Ricardo Plancarte-Sánchez1, Silvia Alarcón-Barrios1
1Clínica del Dolor, Instituto Nacional de Cancerología, Ciudad de México, México.
Cirugia Y Cirujanos
|December 24, 2016
Summary
Complex regional pain syndrome (CRPS) causes disproportionate pain and motor disturbances after injury. Current treatments lack strong evidence, but new technologies offer hope for managing this challenging pain condition.
Area of Science:
- Pain Medicine
- Neurology
- Rehabilitation
Background:
- Complex regional pain syndrome (CRPS) presents with disproportionate pain and regional disturbances following an event, often surgery or trauma.
- Clinical presentations vary widely, complicating diagnosis and treatment.
- The condition is associated with post-traumatic inflammation, peripheral vasomotor dysfunction, and central nervous system maladaptation.
Purpose of the Study:
- To review the current understanding of complex regional pain syndrome (CRPS) pathophysiology, diagnosis, and treatment.
- To highlight the lack of definitive first-line treatments and the emergence of new therapeutic technologies.
Main Methods:
- Diagnosis relies on the Budapest criteria, requiring specific pain, sensory, vasomotor, edema, and motor/trophic symptoms and signs.
- Treatment approaches are multimodal, with no established gold standard.
- Evidence for pharmacological and interventional treatments, including NSAIDs, neuropathic pain agents, bisphosphonates, and advanced therapies, is reviewed.
Main Results:
- No clear first-line treatments have established efficacy for complex regional pain syndrome (CRPS).
- Low evidence supports the effectiveness of treatments like bisphosphonates, calcitonin, ketamine, and mirror therapy compared to placebo.
- Interventional treatments range from epidural blocks to neurostimulation and experimental therapies for intractable pain.
Conclusions:
- Despite being a recognized condition for over a century, definitive first-line treatments for complex regional pain syndrome (CRPS) remain elusive.
- Advancements in technology are leading to the development of new therapeutic options for CRPS management.
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