Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Viruses with RNA Genomes01:29

Viruses with RNA Genomes

1.2K
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
1.2K
Viral Recombination00:57

Viral Recombination

25.5K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
25.5K
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

50.2K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
50.2K
Pharmacokinetics: Drug–Food and Drug–Viral Interactions01:26

Pharmacokinetics: Drug–Food and Drug–Viral Interactions

404
A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of...
404
Protein-protein Interfaces02:04

Protein-protein Interfaces

14.9K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.9K
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

4.6K
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nonstandard viral genomes as engines of viral evolution: ecological roles, evolutionary consequences, and insights from mathematical modeling.

Current opinion in virology·2026
Same author

Bioluminescent sentinel plants enable autonomous diagnostics of viral infections.

Nature communications·2026
Same author

A Modified Cas9 Scaffold Allows Extension of the Virus-Induced Gene Editing Technology to the Large Potyvirus Genus.

Plant biotechnology journal·2026
Same author

Virus induced gene editing using potyviral vectors in Cas12a expressing plants.

Horticulture research·2026
Same author

Cosmic silence and viral noise: transcriptomic crosstalk in <i>Caenorhabditis elegans</i> under simulated space conditions.

Frontiers in microbiology·2026
Same author

Reduced gravity and muon flux absence affect <i>Caenorhabditis elegans</i> life history traits and viral infection.

Microbiology spectrum·2026

Related Experiment Video

Updated: Mar 9, 2026

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
13:56

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

11.7K

Virus-host interactome: Putting the accent on how it changes.

Guillermo Rodrigo1, José-Antonio Daròs2, Santiago F Elena3

  • 1Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas - Universidad Politécnica de Valencia, 46022, Valencia, Spain; Instituto de Biología Integrativa y de Sistemas, Consejo Superior de Investigaciones Científicas - Universitat de València, 46980 Paterna, Spain.

Journal of Proteomics
|December 24, 2016
PubMed
Summary
This summary is machine-generated.

Understanding viral infections requires detailed study of virus-host interactions. New approaches are needed to analyze the dynamic, spatio-temporal evolution of these networks for better disease treatments.

Keywords:
EvolutionProtein networkSystems biologyVirology

More Related Videos

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

11.6K
Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses
05:49

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses

Published on: November 21, 2023

2.6K

Related Experiment Videos

Last Updated: Mar 9, 2026

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
13:56

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

11.7K
Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

11.6K
Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses
05:49

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses

Published on: November 21, 2023

2.6K

Area of Science:

  • Virology
  • Molecular Biology
  • Systems Biology

Background:

  • Viral infections involve complex interactions between viral and host components.
  • Understanding these virus-host interaction networks is key to deciphering viral pathology.
  • Current research aims to unveil the molecular basis of viral diseases.

Purpose of the Study:

  • To highlight the dynamic, spatio-temporal nature of virus-host interaction networks.
  • To advocate for new conceptual paradigms and experimental techniques for studying these networks.
  • To emphasize the importance of molecular plasticity and temporal dynamics in complex diseases.

Main Methods:

  • Characterizing virus-host interaction networks.
  • Analyzing the spatio-temporal evolution of these networks.
  • Investigating molecular plasticity and temporal dynamics in disease mechanisms.

Main Results:

  • Virus-host interaction networks are dynamic in both time and space (plastodynamic).
  • Existing methods overlook the spatio-temporal evolution of these networks.
  • Molecular plasticity and temporal dynamics are fundamental to complex diseases.

Conclusions:

  • A paradigm shift in conceptualization and experimental techniques is needed for virus-host interaction studies.
  • Understanding the dynamic nature of these networks is crucial for improving disease treatments.
  • Modulating these networks holds potential for enhancing therapeutic strategies for complex diseases.