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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

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Toward Precision and Reproducibility of Diffusion Tensor Imaging: A Multicenter Diffusion Phantom and Traveling

E M Palacios¹, A J Martin¹, M A Boss²

¹From the Departments of Radiology and Biomedical Imaging (E.M.P., A.J.M., F.E., Y.S.C., E.L.Y., P.M.).

AJNR. American Journal of Neuroradiology

|December 24, 2016

Summary

Standardizing diffusion tensor imaging (DTI) across multiple 3T MRI scanners from different vendors is feasible. This harmonization is crucial for large-scale neuroimaging research, ensuring reliable data for precision medicine applications.

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Area of Science:

Neuroimaging
Biomarkers
Precision Medicine

Background:

Precision medicine utilizes quantitative biomarkers to minimize patient variability in disease diagnosis, treatment, and prevention.
High-angular-resolution diffusion tensor imaging (DTI) is a key neuroimaging technique.

Purpose of the Study:

To assess intersite variability of a harmonized 3T DTI protocol across 13 scanners from 11 academic medical centers.
To evaluate the feasibility of standardizing DTI for the multi-site "Transforming Research and Clinical Knowledge in Traumatic Brain Injury" study.

Main Methods:

Acquired diffusion MR imaging using a novel isotropic phantom and a traveling volunteer.
Scanned data on thirteen 3T MRI scanners from GE Healthcare, Philips Healthcare, and Siemens.
Calculated means and coefficients of variation for DTI parameters across scanners for each white matter tract.

Main Results:

For the NIST phantom, the coefficient of variation for apparent diffusion coefficient was <3.8%.
For the volunteer, coefficients of variation for primary DTI metrics averaged over the white matter skeleton were <5%.
Large white matter tracts showed good reproducibility (<5% CV), while smaller tracts exhibited higher variability (up to 10% CV).

Conclusions:

The study demonstrates the feasibility of standardizing DTI across different 3T MRI vendors.
This standardization is essential for large-scale neuroimaging research studies.
Harmonized DTI protocols can enhance the reliability of data for precision medicine in traumatic brain injury research.