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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
Published on: October 28, 2020
Systemic right ventricular morphology in the early postoperative course after extracardiac Fontan operation: is there
Sarah Nordmeyer1, Melanie Rohder1, Johannes Nordmeyer1
1Department of Congenital Heart Disease and Paediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany.
Insights
Patients with a right ventricle (RV) as the systemic ventricle after extracardiac Fontan (EC Fontan) surgery experience higher early postoperative morbidity. Intensified management is crucial for these patients to prevent Fontan failure.
Area of Science:
- Cardiology
- Pediatric Surgery
- Congenital Heart Disease
Background:
- The Fontan operation is a palliative procedure for single-ventricle congenital heart defects.
- Extracardiac (EC) Fontan is a common surgical technique.
- Systemic ventricle anatomy (right vs. left) may influence postoperative outcomes.
Purpose of the Study:
- To compare early postoperative outcomes between patients undergoing EC Fontan with a systemic right ventricle (RV) versus a systemic left ventricle (LV).
Main Methods:
- Retrospective analysis of 173 consecutive EC Fontan patients (1995-2013).
- Comparison of pre-, intraoperative, and detailed postoperative hemodynamic variables between RV and LV groups.
- Statistical analysis to identify significant differences in outcomes.
Main Results:
- RV patients exhibited lower mean arterial and systemic perfusion pressures, and higher atrial pressures on postoperative Day 0.
- RV group showed increased intubation time, higher incidence of ascites, and greater need for dialysis.
- RV patients required more prolonged inotropic support, pharmacological pulmonary vascular resistance reduction, and experienced more supraventricular tachyarrhythmias and longer ICU stays.
Conclusions:
- Systemic RV anatomy is associated with significantly higher early postoperative morbidity following EC Fontan.
- Patients with systemic RV require intensified postoperative management strategies to mitigate risks and prevent Fontan failure.
Objectives:
We aimed to compare early postoperative outcome after extracardiac (EC) Fontan operation between patients with right (RV) or left (LV) systemic ventricles.
Methods:
In total, 173 consecutive patients (median age 4 years, median weight 14 kg) underwent EC Fontan between 1995 and 2013. Pre- and intraoperative data as well as detailed postoperative haemodynamic variables were compared between patients with LV [ n = 109 (63%)] and RV [ n = 64 (37%)].
Results:
: RV patients showed significantly lower mean arterial (median 55 vs 59 mmHg, P = 0.04), higher atrial (median 8 vs 6 mmHg, P = 0.03) and comparable pulmonary pressure (median 14 vs 14 mmHg, P = 0.7) as well as lower mean systemic perfusion pressure (median 39 vs 43 mmHg, P = 0.03) on Day 0 after EC Fontan. They suffered from longer intubation time (median 18 vs 12 h, P = 0.008), higher incidence of ascites (46% vs 28%, P = 0.04) and need for dialysis (21% vs 4%, P = 0.003). Prolonged inotropic support (25% vs 8%, P = 0.02) and pharmacological treatment to reduce pulmonary vascular resistance (71% vs 53%, P = 0.002) were more often used in RV patients and they showed more often supraventricular tachyarrhythmia (27% vs 5%, P < 0.001) and a longer intensive care unit-stay (median 4 vs 3 days, P = 0.03). However, early mortality, need for Fontan takedown, use of mechanical circulatory support, pleural effusions and hospital stay were not significantly different between both groups.
Conclusions:
Patients with systemic RV demonstrate higher morbidity in the early postoperative course compared with patients with systemic LV anatomy and require intensified postoperative management to avoid postoperative Fontan failure.
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