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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
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Paradigm Shifts in Ophthalmic Diagnostics.

J Sebag1, Alfredo A Sadun1, Eric A Pierce1

  • 1Dr. Sebag: VMR Institute for Vitreous Macula Retina, Huntington Beach, CA; Dr. Sadun: Doheny Eye Institute/UCLA, Los Angeles, CA; Dr. Pierce: Ocular Genomics Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School.

Transactions of the American Ophthalmological Society
|December 24, 2016
PubMed
Summary

Future ophthalmic diagnostics will shift from disease detection to assessing psychophysical function and genetic health. Non-invasive nanotechnologies will enable early molecular change detection, improving eye health assessments.

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Area of Science:

  • Ophthalmology
  • Medical Diagnostics
  • Nanotechnology

Background:

  • Ophthalmology is shifting focus from disease to health and function.
  • Genotype information is becoming crucial for defining eye conditions.
  • Non-invasive nanotechnologies are needed for early molecular detection.

Purpose of the Study:

  • To illustrate paradigm shifts in ophthalmic diagnostics.
  • To highlight the move towards psychophysical function assessment.
  • To emphasize the integration of genotype and advanced molecular detection.

Main Methods:

  • Selected topics illustrate key paradigm shifts in ophthalmic diagnostics.
  • Future vision evaluation will incorporate psychophysical function beyond visual acuity.
  • Disease definition will integrate genotype with phenotype.

Main Results:

  • Vision assessment can be enhanced by measuring contrast sensitivity, color vision, and macular function.
  • Genetic understanding improves ocular health and disease characterization.
  • Non-invasive nanotechnologies detect pre-pathology molecular changes in ocular tissues.

Conclusions:

  • Ophthalmic diagnostics are poised for significant improvement through paradigm shifts.
  • These shifts focus on psychophysical function, genetic insights, and nanotechnology.
  • The advancements in ophthalmology may guide similar progress in broader healthcare.