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Improvement of early functional atherosclerotic changes in males with hypercholesterolemia after vitamin E
Alenka Borovničar1, Irena Keber2, Ana Stavljenić Rukavina3
1Lek Pharmaceutical and Chemical Company d.d., Ljubljana, Slovenia, Slovenia.
Abstract:
Vitamin E as an antioxidant vitamin reduces the susceptibility of low-density lipoprotein (LDL) cholesterol to oxidation and may have antiatherosclerotic effects. We tested the hypothesis that six months of 400 mg vitamin E supplementation favourably affects early functional changes in atherosclerotic process in subjects with hypercholesterolemia. The diameter of the brachial artery at rest, after reactive hyperemia (representing endothelium -dependent vasodilatation) and after sublingual glyceryl -trinitrate (representing endothelium - independent vasodilatation), were determined by ultrasonographic method (B mode) before and after the intervention period. After the intervention period the brachial endothelium - dependent vasodilatation increased significantly in the vitamin E group while it did not change in the placebo group. In conclusion, six months of oral vitamin E supplementation results in improvement of the endothelium - dependent vasodilatation in men with hypercholesterolemia.
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