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The overexpressed functional transient receptor potential channel TRPM2 in oral squamous cell carcinoma

Ling-Yan Zhao1, Wan-Lin Xu1,2, Zeng-Qi Xu1

  • 1Jiangsu Key Laboratory of Oral Diseases and Department of Oral and maxillofacial surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029, China.

Scientific Reports
|December 24, 2016
PubMed

Insights

Transient Receptor Potential Melastatin 2 (TRPM2) channels are upregulated in tongue cancer, promoting cancer cell survival and migration. Inhibiting TRPM2 shows potential for targeted tongue cancer therapies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Biology

Background:

  • Transient Receptor Potential Melastatin 2 (TRPM2) is a calcium-permeable channel activated by oxidative stress.
  • TRPM2 is implicated in cell death pathways and its role in cancer is under investigation.

Purpose of the Study:

  • To investigate the role of TRPM2 in tongue squamous cell carcinoma (SCC).
  • To explore TRPM2 as a potential therapeutic target for tongue cancer.

Main Methods:

  • Enhanced TRPM2 expression was observed in tongue carcinoma tissues and cell lines.
  • Electrophysiological recordings identified ADPR-induced currents mediated by TRPM2 in SCC9 cells.
  • TRPM2 was selectively knocked down using small interfering RNA (siRNA).
  • Cell survival, migration, and apoptosis were assessed after TRPM2 knockdown.
  • Sub-cellular localization of TRPM2 was analyzed.

Main Results:

  • TRPM2 expression was enhanced in tongue carcinoma.
  • TRPM2 knockdown inhibited SCC cell survival and migration, independent of the p53-p21 pathway.
  • TRPM2 localized to the nucleus in cancer cells, differing from non-cancerous cells.
  • Hydrogen peroxide (H2O2) treatment increased SCC9 cell apoptosis.

Conclusions:

  • TRPM2 is crucial for the survival and migration of tongue SCC cells.
  • TRPM2 represents a potential therapeutic target for tongue cancer treatment.

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