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A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies
Ramon Subiros-Funosas1, Lorena Mendive-Tapia2, Jesus Sot3
1MRC/UoE Centre for Inflammation Research, The University of Edinburgh, 47 Little France Crescent, EH16 4TJ Edinburgh, UK. marc.vendrell@ed.ac.uk.
Abstract:
The rational design and synthesis of a Trp-BODIPY cyclic peptide for the fluorescent labelling of apoptotic bodies is described. Affinity assays, confocal microscopy and flow cytometry analysis confirmed the binding of the peptide to negatively-charged phospholipids associated with apoptosis, and its applicability for the detection and characterisation of subcellular structures released by apoptotic cells.
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