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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Related Experiment Video

Updated: Mar 9, 2026

Cerebrospinal Fluid MicroRNA Profiling Using Quantitative Real Time PCR
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Expression profile of long noncoding RNAs in human cerebral aneurysms: a microarray analysis.

Hao Li1,2, Haiyan Yue3,4,5, Yajing Hao3,4,5

  • 1Department of Neurosurgery and.

Journal of Neurosurgery
|December 24, 2016
PubMed
Summary

This study reveals long noncoding RNAs (lncRNAs) are differentially expressed in cerebral aneurysms (CAs), suggesting their role in CA pathogenesis through immune and vascular pathways. These findings offer new therapeutic targets for CA treatment.

Keywords:
CA = cerebral aneurysmCCL5 = chemokine ligand 5GO = gene ontologyKEGG = Kyoto Encyclopedia of Genes and GenomesRT-qPCR = reverse-transcription quantitative polymerase chain reactionSAH = subarachnoid hemorrhageSMC = smooth muscle cellSTA = superficial temporal arterycerebral aneurysmsinflammationlncRNA = long non-coding RNAlong noncoding RNAmRNA = messenger RNApathogenesisvascular disordersvascular smooth muscle contraction

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Area of Science:

  • Genomics
  • Molecular Biology
  • Vascular Biology

Background:

  • The precise mechanisms underlying cerebral aneurysm (CA) pathogenesis are not fully understood.
  • Long noncoding RNAs (lncRNAs) are increasingly recognized for their significant roles in various biological processes.

Purpose of the Study:

  • To investigate the differential expression of lncRNAs and messenger RNAs (mRNAs) in cerebral aneurysms (CAs) compared to control arteries.
  • To explore the potential functions and regulatory networks of lncRNAs in CA formation.

Main Methods:

  • A prospective case-control study comparing 12 saccular CA samples with 12 paired superficial temporal artery samples.
  • Microarray analysis for lncRNA and mRNA expression profiling, validated by reverse-transcription quantitative polymerase chain reaction.
  • lncRNA-mRNA interaction network construction, gene ontology, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses.

Main Results:

  • Identified 1518 differentially expressed lncRNAs and 2545 differentially expressed mRNAs between CA and control groups.
  • Constructed a network of 2786 lncRNA-mRNA pairs, highlighting complex regulatory interactions.
  • lncRNAs were found to be primarily involved in immune/inflammatory pathways and vascular smooth muscle contraction.

Conclusions:

  • An expression profile of lncRNAs in CAs was established, proposing their involvement in CA pathogenesis.
  • lncRNAs play significant roles in regulating key pathways relevant to CA formation, including inflammation and vascular smooth muscle function.
  • This research provides novel insights into CA mechanisms and potential avenues for future therapeutic interventions.