Related Experiment Video

Updated: Sep 2, 2026

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
08:46

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Published on: September 1, 2015

Effect of congenital renal disease and neonatal thyroid status on urinary human epidermal growth factor

S M Scott1, C Guardian, C Rogers

  • 1Pediatric Research Laboratory, Children's Hospital, Albuquerque, New Mexico.

Acta Endocrinologica
|October 1, 1989
PubMed

Insights

Urinary epidermal growth factor (EGF) excretion in newborns is affected by thyroid and kidney function. Renal disease and hypothyroidism decrease EGF excretion, while hyperthyroidism increases it.

Area of Science:

  • Neonatal physiology
  • Endocrinology
  • Nephrology

Background:

  • Urinary epidermal growth factor (EGF)/creatinine ratios correlate with gestational age and gender.
  • Chronic renal disease and thyroid dysfunction impact EGF and creatinine excretion in older individuals.
  • The control of perinatal EGF excretion patterns remains unclear.

Purpose of the Study:

  • To investigate the influence of congenital renal disease and thyroid function on EGF excretion during the perinatal period.
  • To compare EGF and creatinine excretion in infants with specific conditions to healthy controls.

Main Methods:

  • Collected and analyzed urine samples from infants with congenital renal disease, low T4/normal TSH, hypothyroidism, and neonatal Grave's disease.
  • Compared EGF and creatinine excretion values with those from 190 healthy infants.
  • Examined changes in EGF excretion following relief of urinary obstruction.

Main Results:

  • EGF excretion increases earlier in gestation compared to creatinine excretion.
  • Infants with renal disease or hypothyroidism exhibited decreased EGF excretion.
  • Hyperthyroidism was associated with enhanced EGF excretion.
  • Relief of urinary obstruction led to increased EGF excretion, though levels remained low; creatinine excretion was unaffected.

Conclusions:

  • Thyroid and renal diseases significantly alter EGF excretion in preterm infants, mirroring effects seen in childhood.
  • EGF excretion is sensitive to renal function and thyroid status during early development.

More Related Videos

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells09:40

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells

Published on: June 20, 2018

Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts05:56

Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts

Published on: January 22, 2020

Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance01:25

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance (Clcr), a...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...