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Movement Initiation Signals in Mouse Whisker Motor Cortex.

Varun Sreenivasan1, Vahid Esmaeili2, Taro Kiritani2

  • 1Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland; Centre for Developmental Neurobiology, King's College London, London SE1 1UL, UK.

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Summary

Sensory input from the whisker somatosensory cortex (wS1) influences motor cortex (wM1) control of whisking. wS1 stimulation drives wM1 activity and modulates whisking, highlighting sensory control of motor cortex functions.

Keywords:
action potentialmembrane potentialmotor codingmotor cortexmovement initiationmultisite silicon probe recordingoptogeneticssensorimotor integrationwhisker motor controlwhole-cell recording

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Area of Science:

  • Neuroscience
  • Motor Control
  • Sensory Processing

Background:

  • The frontal cortex is crucial for voluntary movement control, often guided by sensory information.
  • The whisker primary motor cortex (wM1) is a frontal region densely innervated by the whisker primary somatosensory cortex (wS1).

Purpose of the Study:

  • To investigate the functional role of mouse whisker primary motor cortex (wM1) in motor control.
  • To elucidate the influence of whisker primary somatosensory cortex (wS1) input on wM1 activity and whisking behavior.

Main Methods:

  • Optogenetic stimulation and inactivation of wM1 and wS1 in mice.
  • Whole-cell membrane potential recordings and silicon probe recordings of neuronal activity.
  • Analysis of neuronal activity during whisking initiation and execution.

Main Results:

  • Optogenetic stimulation of wM1 evoked rhythmic whisking; inactivation suppressed whisking initiation.
  • Layer-specific neuronal activity in wM1 was observed at movement initiation and encoded movement parameters.
  • Inactivation of wS1 led to reduced wM1 activity and whisking.
  • Stimulation of wS1 induced complex wM1 activity and long-latency whisking.

Conclusions:

  • wM1 plays a critical role in initiating and controlling whisking movements.
  • Sensory input from wS1 significantly influences wM1 activity and motor output.
  • These findings underscore the importance of sensory-motor integration in voluntary movement control.