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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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Hypocortisolism and preterm birth.

S D Karakash1, N Tschankoshvili2, J Weedon3

  • 1Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, NY, USA.

Journal of Neonatal-Perinatal Medicine
|December 24, 2016
PubMed
Summary
This summary is machine-generated.

Women experiencing preterm birth had lower hair cortisol levels, indicating hypocortisolism. This suggests an impaired stress response may increase preterm birth risk.

Keywords:
Hair cortisolpreterm birthstress in pregnancystress response

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Area of Science:

  • Endocrinology
  • Reproductive Health
  • Psychoneuroendocrinology

Background:

  • Hypothalamic-pituitary-adrenal (HPA) axis activity is crucial for stress response.
  • Hair cortisol offers a retrospective measure of long-term HPA axis function.
  • The association between hypocortisolism and preterm birth remains under investigation.

Purpose of the Study:

  • To investigate the relationship between hypocortisolism, measured by hair cortisol, and preterm birth.
  • To determine if lower hair cortisol levels are associated with delivering prematurely.

Main Methods:

  • A prospective, matched case-control study compared 29 women with preterm birth to 29 term birth controls.
  • Hair cortisol levels were measured and compared between groups.
  • Validated questionnaires assessed stress and childhood trauma.
  • Statistical analyses included Wilcoxon signed-rank test and conditional logistic regression.

Main Results:

  • Women with preterm birth exhibited significantly lower hair cortisol levels compared to term birth controls.
  • Lower hair cortisol levels were a predictor of preterm birth, with decreased odds associated with increased hair cortisol.
  • The preterm group reported higher levels of emotional neglect.

Conclusions:

  • Preterm birth may be associated with hypocortisolism, indicated by lower hair cortisol levels.
  • An inadequate physiological stress response, despite experiencing stress, could elevate the risk of preterm birth.