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Published on: January 26, 2019
Use of Cellular Decapping Activators by Positive-Strand RNA Viruses
Jennifer Jungfleisch1, Bernat Blasco-Moreno2, Juana Díez3
1Molecular Virology Laboratory, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona 08003, Spain. Jennifer.Jungfleisch@upf.edu.
Abstract:
Positive-strand RNA viruses have evolved multiple strategies to not only circumvent the hostile decay machinery but to trick it into being a priceless collaborator supporting viral RNA translation and replication. In this review, we describe the versatile interaction of positive-strand RNA viruses and the 5'-3' mRNA decay machinery with a focus on the viral subversion of decapping activators. This highly conserved viral trickery is exemplified with the plant Brome mosaic virus, the animal Flock house virus and the human hepatitis C virus.
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