Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

4.3K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
4.3K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

10.2K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
10.2K
Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

9.7K
Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
9.7K
Paracrine Signaling01:21

Paracrine Signaling

60.1K
Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...
60.1K
Introduction to Hemostasis01:05

Introduction to Hemostasis

15.7K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
15.7K
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

9.8K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
9.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Murine thrombus organization limits access to high platelet activation states while supporting platelet recruitment.

Blood vessels, thrombosis & hemostasis·2026
Same author

The Syk inhibitor BI 1002494 impairs thrombus infill in a murine femoral artery occlusion without affecting hemostasis.

Blood vessels, thrombosis & hemostasis·2025
Same author

Uncovering the role of the Hsp40 family member cysteine string protein-α in mouse platelets.

Blood advances·2025
Same author

Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure.

International journal of molecular sciences·2025
Same author

Leaf miRNAs of Withania somnifera Negatively Regulate the Aging-Associated Genes in C. elegans.

Molecular neurobiology·2025
Same author

Densely Populated Cell and Organelles Segmentation with U-Net Ensembles.

bioRxiv : the preprint server for biology·2024
Same journal

Hexokinase controls platelet activation and hemostasis.

Platelets·2026
Same journal

Chemiluminescence resonance energy transfer-based method to investigate the platelet surface molecule in acute myocardial infarction.

Platelets·2026
Same journal

Nanobodies to GPVI as alternative reagents for platelet spreading.

Platelets·2026
Same journal

Neural network reveals platelet age from fluorescence microscopy images.

Platelets·2026
Same journal

Sixty years of research into ancestry differences in platelet function.

Platelets·2026
Same journal

Platelet-rich plasma concentrations regulate MSCs osteogenesis via MAPK/PI3K-AKT pathways to mitigate inflammatory bone loss.

Platelets·2026
See all related articles

Related Experiment Video

Updated: Mar 9, 2026

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow
11:42

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow

Published on: July 10, 2017

12.3K

The cellular basis of platelet secretion: Emerging structure/function relationships.

Shilpi Yadav1, Brian Storrie1

  • 1a Department of Physiology and Biophysics , University of Arkansas for Medical Sciences , Little Rock , AR , USA.

Platelets
|December 25, 2016
PubMed
Summary
This summary is machine-generated.

Platelet secretion involves multiple compartments, including alpha-granules. Recent high-resolution imaging reveals new insights into alpha-granule structure and function, advancing platelet cell biology research.

Keywords:
Alpha-granulesmicroscopyplatelets, platelet release reactionsecretion

More Related Videos

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry
08:04

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

1.8K
Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.3K

Related Experiment Videos

Last Updated: Mar 9, 2026

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow
11:42

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow

Published on: July 10, 2017

12.3K
Analyzing Platelet Subpopulations by Multi-color Flow Cytometry
08:04

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

1.8K
Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.3K

Area of Science:

  • Cell Biology
  • Hematology
  • Biochemistry

Background:

  • Platelets secrete contents from dense granules, alpha-granules, and lysosomes.
  • Unanswered questions persist regarding platelet secretory organelle organization and cargo release routes.
  • Emerging evidence suggests secretion from dense tubular system and Golgi apparatus.

Purpose of the Study:

  • To review the cell biology of platelet alpha-granules.
  • To explore alpha-granule structure/function relationships.
  • To discuss advanced 3D structural imaging techniques in platelet research.

Main Methods:

  • Literature review of platelet secretion.
  • Analysis of 3-dimensional, high-resolution structural imaging data.
  • Discussion of emerging findings in platelet cell biology.

Main Results:

  • Alpha-granules are major protein storage organelles in platelets.
  • Advanced imaging reveals novel aspects of alpha-granule structure.
  • New insights into the cell biology of platelet secretion are emerging.

Conclusions:

  • Platelet secretion is a complex process involving multiple organelles.
  • High-resolution structural studies are crucial for understanding platelet function.
  • Further research promises to resolve controversies and yield clinical relevance.