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A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
Published on: June 20, 2017
Prospective memory 7 years after severe childhood traumatic brain injury - the TGE 2 prospective longitudinal study
Agata Krasny-Pacini1,2,3,4, Leila Francillette5, Hanna Toure6
1a Outreach Department for Patients with Acquired Brain Injury, University Rehabilitation Institute Clemenceau-Strasbourg , Strasbourg , France.
Objective:
To investigate the long-term outcome in prospective memory (PM), seven years after childhood severe traumatic brain injury (TBI), in a prospective longitudinal cohort.
Participants:
76 young individuals (aged 7-22 years): 39 patients with a severe accidental TBI included prospectively seven years earlier, aged 0-15 years at injury, and 37 controls individually matched on age, gender and parental education.
Main Outcome Measures:
Three novel short PM tasks varying in the delay, motivation and context (ecological versus paper and pencil task).
Results:
Individuals with severe TBI showed significantly poorer PM than matched controls in the two low-motivation PM tasks: (1) the ecological long-delay task consisting of sending a letter on a rainy day (p=0.047, odds ratio = 2.6); (2) the non-ecological short-delay task consisting of taking off post-its while identifying facial emotions (p=0.004, r=0.34). Differences in PM on the high motivation were not significant. PM is impaired several years post severe TBI.
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