Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Delayed decrease in hemispheric cerebral blood flow during Wada test demonstrated by 99mTc-HMPAO single photon

E Ryding1, H Sjöholm, H Skeidsvoll

  • 1Department of Clinical Neurophysiology, University Hospital, Lund, Sweden.

Acta Neurologica Scandinavica
|September 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The combined burden of cognitive, executive function, and psychosocial problems in children with epilepsy: a population-based study.

Developmental medicine and child neurology·2008
Same author

Regional cerebral metabolic rate (positron emission tomography) during inhalation of nitrous oxide 50% in humans.

British journal of anaesthesia·2007
Same author

Focal epileptiform activity described by a large computerised EEG database.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2007
Same author

Executive functions and seizure-related factors in children with epilepsy in Western Norway.

Developmental medicine and child neurology·2006
Same author

Electroencephalography and magnetic resonance imaging in neurological decompression sickness.

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc·2006
Same author

Psychosocial problems and seizure-related factors in children with epilepsy.

Developmental medicine and child neurology·2006

This study shows how to visualize brain flow decreases during a Wada test using 99mTc-HMPAO. Optimal timing of tracer injection is crucial for accurate visualization of reduced cerebral blood flow and crossed cerebellar diaschisis.

Area of Science:

  • Neuroscience
  • Radiology
  • Nuclear Medicine

Background:

  • The Wada test is used to assess hemispheric brain function.
  • Visualizing regional cerebral blood flow (rCBF) changes during the Wada test is essential for accurate interpretation.

Purpose of the Study:

  • To describe a method for visualizing brain regions with decreased flow and metabolism during a Wada test.
  • To determine the optimal timing for intravenous tracer administration to accurately depict these hypoperfused areas.

Main Methods:

  • Utilized short-acting barbiturate injection into the internal carotid artery during a Wada test.
  • Administered intravenous 99mTc-HMPAO (Ceretec) to mark relative cerebral blood flow distribution.
  • Acquired 3D brain imaging approximately 1 hour post-injection using single photon emission computed tomography (SPECT).

Related Experiment Videos

Main Results:

  • Demonstrated that delayed intravenous 99mTc-HMPAO administration (at least 30 seconds after barbiturate effect onset) is critical for visualizing low-flow regions.
  • Observed a decrease in rCBF in the barbiturate-injected hemisphere.
  • Documented a simultaneous decrease in the contralateral cerebellar hemisphere, consistent with crossed cerebellar diaschisis.

Conclusions:

  • The timing of 99mTc-HMPAO administration is a key factor in accurately visualizing hypoperfusion during the Wada test.
  • This method allows for the detection of both direct effects of barbiturate on the cerebral hemisphere and indirect effects on the cerebellum (crossed cerebellar diaschisis).