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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Nail involvement in systemic sclerosis.

Isabelle Marie1, Vincent Gremain1, Kladoum Nassermadji1

  • 1Department of Internal Medicine, Rouen University Hospital, Rouen, France; Institut National de la Santé et de la Recherche Médicale U 905, University of Rouen Institut Fédératif Multidisciplinaire sur les Peptides, Institute for Biochemical Research, Rouen, France.

Journal of the American Academy of Dermatology
|December 25, 2016
PubMed
Summary
This summary is machine-generated.

Fingernail changes are common in systemic sclerosis (SSc), affecting over 80% of patients. These nail abnormalities correlate with more severe SSc, indicating digital microangiopathy.

Keywords:
diagnosisdigital ulcersnail involvementpredictive factorsystemic sclerosis

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Area of Science:

  • Rheumatology
  • Dermatology
  • Nail Medicine

Background:

  • Nail involvement in systemic sclerosis (SSc) is infrequently documented.
  • Previous studies on SSc nail changes are limited, often consisting of case reports.

Purpose of the Study:

  • To determine the prevalence of fingernail changes in patients with systemic sclerosis (SSc).
  • To assess the association between fingernail alterations and other clinical features of SSc.

Main Methods:

  • A case-control study involving 129 SSc patients and 80 healthy controls.
  • Routine fingernail examinations were conducted on all participants.

Main Results:

  • Fingernail changes were observed in 80.6% of SSc patients.
  • SSc patients exhibited significantly higher rates of trachyonychia, scleronychia, thickened nails, brachyonychia, parrot beaking, pterygium inversum unguis, splinter hemorrhages, and cuticle abnormalities compared to controls.
  • Fingernail changes were linked to digital ulcers, calcinosis cutis, and elevated nailfold videocapillaroscopy scores.

Conclusions:

  • Fingernail changes are prevalent in SSc and associated with more severe disease manifestations, including digital microangiopathy.
  • Systematic nail assessment in SSc patients is recommended.
  • Nail changes may warrant consideration for inclusion in SSc classification criteria.