¹³¹I-labeled and DOX-loaded multifunctional nanoliposomes for radiotherapy and chemotherapy in brain gliomas

The codelivery of different therapeutics is a promising option because of its synergetic effects of drugs. In this study, a new combination therapy that used the doxorubicin-loaded and ¹³¹I-labeled nanoliposomes (¹³¹I-DOX-NL) was proposed to delay tumor growth of gliomas, which are characterized by significant mortality and morbidity. ¹³¹I-DOX-NL was constructed based on bovine serum albumin (BSA)-tailor made hydrophobic maleimide-functionalized poly(ε-caprolactone) (PCL) (Fig. 1) and was evaluated by cellular viability in vitro and by U87 xenograft models in vivo. Compared with using ¹³¹I-NL or DOX-NL alone, our experimental results show that ¹³¹I-DOX-NL exhibits similar high cellular uptake but enhanced efficacy to cure gliomas because of its codelivery of ¹³¹I and DOX. In the U87 mouse tumor models, the combination therapy resulted in higher survival rates of mice and smaller tumor sizes than monotherapy did alone. In conclusion, multifunctional nanoliposome ¹³¹I-DOX-NL is a good candidate for the codelivery of ¹³¹I-mediated radiotherapy and DOX-mediated chemotherapy due to its ability to inhibit U87 cell proliferation and tumor growth. ¹³¹I-DOX-NL can be used as a promising effective therapy for malignant gliomas and deserves further investigation.