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Clinicopathological Implication of Insulin-like Growth Factor-II mRNA-Binding Protein 3 (IMP3) Expression in Gastric

Dakeun Lee1, Eun Ji Yu1, In-Hye Ham2,3

  • 1Department of Pathology, Ajou University School of Medicine, Suwon, Republic of Korea.

Anticancer Research
|December 25, 2016
PubMed
Abstract

Insights

High expression of human insulin-like growth factor II mRNA-binding protein 3 (IMP3) in gastric cancer indicates a poorer prognosis. IMP3 may serve as a predictive biomarker for advanced disease and lymph node metastasis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biomarker Discovery

Background:

  • The clinicopathological significance of the oncofetal mRNA-binding protein, human insulin-like growth factor II mRNA-binding protein 3 (IMP3), in gastric carcinoma (GC) requires further elucidation.
  • IMP3 is an oncofetal protein with potential roles in cancer development and progression.

Purpose of the Study:

  • To investigate the clinicopathological significance and prognostic value of IMP3 expression in gastric carcinoma.
  • To evaluate IMP3 as a potential biomarker for advanced GC and lymph node metastasis.

Main Methods:

  • Tissue microarray blocks from 346 GC patients were analyzed for IMP3 expression.
  • Results were validated using an online dataset of 876 GC patients (Kaplan-Meier Plotter).
  • Serum IMP3 levels were compared between 57 GC patients and 15 controls.

Main Results:

  • High IMP3 expression was significantly associated with poor prognosis in GC patients.
  • Validation analysis confirmed that high IMP3 expression correlated with worse disease-free survival and overall survival.
  • Preliminary analysis suggested IMP3 overexpression might predict advanced disease or lymph node metastasis.

Conclusions:

  • Tissue overexpression of IMP3 is linked to poorer prognosis in gastric carcinoma.
  • IMP3 may serve as a valuable predictor for advanced GC, lymph node metastasis, and unfavorable outcomes.
Keywords:
Gastric cancerinsulin-like growth factor-II mRNA-binding protein 3prognosis

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