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Objective Predictive Score as a Feasible Biomarker for Short-term Survival in TerminalIy Ill Patients with Cancer
Yoshinaga Okugawa1,2,3, Yumiko Shirai4, Hiroko Nodono5
1Department of Surgery, Iga City General Hospital, Mie, Japan yoshinaga.okugawa@gmail.com harborne3030@gmail.com.
Background:
In palliative care, prediction of life expectancy is one of the most crucial issues for patients, family and medical staff, in order to provide appropriate end-of-life care. The aim of this study was to formulate a new objective score to predict life expectancy within 1 week for terminally ill patients with cancer.
Patients And Methods:
Medical records were obtained from 187 terminally-ill patients with cancer who were admitted for palliative care. The biomarkers for a potential 'Objective Predictive Score' were assessed.
Results:
Profiling of blood parameters demonstrated that elevated levels of alanine aminotransferase (ALT), total bilirubin (T-bil), blood urea nitrogen (BUN), creatinine (Cr) and a decreased platelet count were significantly correlated with death within 1 week in a training cohort. Our formulated Objective Predictive Score was able to predict death within 1 week with high accuracy in a training and a validation cohort.
Conclusion:
Our scoring system might enable the assessment of prognostication with higher accuracy in a terminal care setting.
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