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Lymphocyte function in major depression.

L L Altshuler1, S Plaeger-Marshall, S Richeimer

  • 1Department of Psychiatry, UCLA School of Medicine.

Acta Psychiatrica Scandinavica
|August 1, 1989
PubMed
Summary
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Depressed patients showed a significantly increased lymphocyte response to phytohemagglutinin (PHA) mitogen compared to healthy individuals. This study highlights potential immune system alterations in major depression.

Area of Science:

  • Psychiatry
  • Immunology
  • Cellular Biology

Background:

  • Major depression is a prevalent mood disorder.
  • Alterations in immune function have been suggested in psychiatric conditions.
  • Lymphocyte response to mitogens is a measure of cellular immunity.

Purpose of the Study:

  • To investigate immunologic function in patients with major depression.
  • To compare lymphocyte PHA response in depressed patients versus healthy controls.
  • To explore the variance in immune response within the depressed group.

Main Methods:

  • Evaluating lymphocyte response to phytohemagglutinin (PHA) mitogen.
  • Assessing 8 psychiatric inpatients with DSM-III diagnosis of major depression (age < 45).
  • Comparing patient responses to age- and sex-matched healthy controls.

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Main Results:

  • A significant increase in PHA mitogen stimulation was observed in the depressed group.
  • A significantly greater variance in PHA response was noted in depressed patients compared to controls.
  • The findings suggest a distinct immunologic profile in major depression.

Conclusions:

  • Major depression may be associated with altered cellular immune function.
  • Increased PHA response and greater response variance in depressed patients warrant further investigation.
  • These findings have potential clinical implications for understanding depression and immunity.