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Association of antenatal antithrombin activity with perinatal liver dysfunction: A prospective multicenter study
Mamoru Morikawa1, Hirotada Suzuki2, Mana Obata-Yasuoka3
1Department of Obstetrics, Hokkaido University Hospital, Sapporo, Japan.
Journal of Gastroenterology and Hepatology
|December 25, 2016
Summary
Reduced antithrombin (AT) activity, even without thrombocytopenia, can predict life-threatening liver dysfunction in pregnant women. Monitoring AT levels may improve maternal safety during pregnancy.
Area of Science:
- Perinatal Medicine
- Hepatology
- Hematology
Background:
- Liver dysfunction and thrombocytopenia pose significant risks to pregnant women.
- The predictive value of antithrombin (AT) activity for liver dysfunction in pregnancy is not well-established.
Purpose of the Study:
- To investigate the clinical utility of antenatal antithrombin (AT) activity and platelet count (PLC) in predicting perinatal liver dysfunction.
Main Methods:
- Prospective cohort study of 541 pregnant women registered at gestational week 34.7.
- Antenatal AT activity and platelet count (PLC) data were analyzed in relation to the occurrence of liver dysfunction.
Main Results:
- Lower antenatal AT activity and PLC were observed in women who developed perinatal liver dysfunction.
- Reduced AT activity, even without thrombocytopenia, was identified in women with liver dysfunction.
- Combined AT and PLC offered improved sensitivity (73%) for predicting perinatal liver dysfunction.
Conclusions:
- Antithrombin (AT) deficiency can precede liver dysfunction in pregnant women, independent of thrombocytopenia.
- Monitoring AT levels may enhance the clinical management and safety of pregnant women at risk for liver dysfunction.
Keywords:
HELLP syndromeacute fatty liver of pregnancyantithrombin activitydisseminated intravascular coagulationmaternal mortalitypregnancy complicationMore Related Videos
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