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Neuromyelitis optica in the elderly.

F Barbieri, G A Buscaino

    Acta Neurologica
    |August 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    This case highlights neuromyelitis optica (NMO) occurring in an elderly patient, presenting with acute transverse myelitis and optic neuritis. Despite treatment, the patient

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    Area of Science:

    • Neurology
    • Immunology
    • Neuroimmunology

    Background:

    • Neuromyelitis optica (NMO) is an autoimmune demyelinating disease affecting the optic nerves and spinal cord.
    • While typically diagnosed in younger individuals, late-onset NMO can occur.

    Observation:

    • A 68-year-old woman presented with acute transverse myelitis and monolateral optic neuritis.
    • Cerebrospinal fluid (CSF) analysis revealed elevated protein, pleocytosis, increased IgG, and one oligoclonal band.
    • Spinal MRI showed T2-weighted hyperintensities in cervical and thoracic tracts.

    Findings:

    • Clinical, laboratory, and neuroimaging data were consistent with NMO.
    • The patient's condition was refractory to intensive steroid therapy, leading to a fatal outcome within 6 weeks.

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  • This case suggests NMO can manifest initially in advanced age.

    • Implications:

    • This case underscores the importance of considering NMO in elderly patients presenting with myelitis and optic neuritis.
    • It highlights the potential for late-onset autoimmune neurological disorders.
    • Further research into NMO's pathophysiology and treatment in older populations is warranted.