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Inhibition of neutrophil adherence to endothelial cells by 3-deazaadenosine
C H Jurgensen1, G Wolberg, T P Zimmerman
1Wellcome Research Laboratories, Research Triangle Park, NC 27709.
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|June 1, 1989
Abstract:
Treatment of cultured human umbilical vein endothelial cells (HUVE) with tumor necrosis factor alpha (TNF-alpha) increases their capacity to adhere human neutrophils. We have found that 3-deazaadenosine (c3Ado), when added in conjunction with TNF-alpha, inhibited this increase in neutrophil adherence. This activity of c3Ado was potentiated by the addition of L-homocysteine thiolactone (Hcy). The ability of c3Ado to inhibit neutrophil adherence to HUVE may contribute to the anti-inflammatory activity of this nucleoside analogue.