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Rest-activity patterns and falls and fractures in older men
Tara S Rogers1, Terri L Blackwell2, Nancy E Lane3
1Center for Musculoskeletal Health and Department of Internal Medicine, University of California, Davis Medical Center, 4625 2nd Avenue, Suite 2000, Sacramento, CA, 95817, USA. tsrogers@ucdavis.edu.
Summary
Later sleep-wake cycles (acrophase) in older men increase fall risk but not fracture risk. Further research is needed on dysregulated rest-activity patterns and osteoporosis.
Area of Science:
- Gerontology
- Chronobiology
- Epidemiology
Background:
- Dysregulated rest-activity rhythm (RAR) is linked to health issues in older adults.
- Understanding RAR's impact on falls and fractures is crucial for elderly men's health.
Purpose of the Study:
- To investigate the relationship between rest-activity rhythm (RAR) patterns and the risk of falls and fractures in older men.
- To test the hypothesis that dysregulated RAR is associated with increased incident falls and fractures.
Main Methods:
- Utilized wrist-worn actigraphy to measure RAR in 3001 men (≥67 years) from the MrOS Sleep Study.
- Assessed RAR parameters including amplitude, mesor, acrophase, and rhythm robustness over multiple 24-hour periods.
- Employed logistic and proportional hazards models to analyze associations between RAR and recurrent falls/fractures, adjusting for confounders.
Main Results:
- A later acrophase was associated with a modestly increased likelihood of recurrent falls (OR 1.18).
- No significant associations were found between RAR patterns and major osteoporotic fractures, spine fractures, or hip fractures.
- Follow-up data over 8.6 years revealed no consistent link between RAR and fracture risk.
Conclusions:
- Later acrophase is linked to a higher risk of falls in elderly men.
- This association between later acrophase and falls did not extend to an increased risk of fractures in the studied cohort.
- The connection between dysregulated RAR patterns and osteoporosis risk requires additional investigation.
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